Fiszki Anki: Gastrointestinal Pharmacology, Proton Pump Inhibitors, Antacids
Inne • 50 fiszek • alicjaradomska34 • pobrane 0 razy
Talia „Gastrointestinal Pharmacology, Proton Pump Inhibitors, Antacids" to 50 gotowych fiszek Anki z kategorii Inne, udostępnionych w publicznej bibliotece YourAnki przez alicjaradomska34. Do tej pory pobrano ją 0 razy.
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Zagadnienia w tej talii
- Proton Pump Inhibitors
- Antacids
- Gastrointestinal Pharmacology
- Pharmacology
Przykładowe fiszki
Pytanie
What intrinsic defense mechanisms protect the stomach from gastric acid and pepsin damage?
Odpowiedź
The stomach is protected by "mucosal defense" mechanisms, many of which are stimulated by local generation of Prostaglandins (PGs) and Nitric Oxide (NO).
Pytanie
What role does Helicobacter pylori play in acid-peptic diseases?
Odpowiedź
Helicobacter pylori plays a key role in the pathogenesis of acid-peptic diseases.
Pytanie
What are the three main types of factors that regulate H+ secretion by parietal cells?
Odpowiedź
Gastric acid secretion is regulated by neuronal (ACh, GRP), paracrine (histamine), and endocrine (gastrin) factors.
Pytanie
What is the primary oesophageal defense against reflux of gastric contents?
Odpowiedź
The primary oesophageal defense is the gastroesophageal junction, where the lower oesophageal sphincter prevents reflux of acidic gastric contents into the oesophagus.
Pytanie
How do PPIs suppress acid production?
Odpowiedź
PPIs irreversibly inactivate the H+, K+-ATPase (proton pump) molecule, blocking the final step in acid production. Acid secretion resumes only after new pump molecules are synthesized.
Pytanie
Why should PPIs be given before the first meal of the day?
Odpowiedź
The amount of pump molecules increases after fasting, so PPIs should be given before the first meal of the day for optimal effect.
Pytanie
In what conditions are prescription PPIs primarily used?
Odpowiedź
Prescription PPIs are primarily used to promote healing of gastric and duodenal ulcers, treat gastroesophageal reflux disease (GERD) and erosive esophagitis, eradicate Helicobacter pylori in conjunction with antibiotics, and for pathological hypersecretory conditions like Zollinger-Ellison syndrome.
Pytanie
What are the common side effects of PPIs?
Odpowiedź
The most common side effects of PPIs are nausea, abdominal pain, constipation, and diarrhea. Subacute myopathy, arthralgias, headaches, interstitial nephritis, and skin rashes have also been reported.
Pytanie
What is the mechanism of action of dimethicone/simethicone in antacid preparations?
Odpowiedź
Dimethicone/simethicone are surfactants that decrease foaming and therefore can reduce esophageal reflux.
Pytanie
How do antacids containing Al, Ca, or Mg differ in absorption compared to those containing NaHCO3?
Odpowiedź
Antacids that contain Al, Ca, or Mg are absorbed less completely than those that contain NaHCO3.
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